Target Genes of Autism Risk Loci in Brain Frontal Cortex
نویسندگان
چکیده
منابع مشابه
Reduced minicolumns in the frontal cortex of patients with autism.
Cell minicolumns were shown to be narrower in frontal regions in brains of autistic patients compared with controls. This was not found in primary visual cortex. Within the frontal cortex, dorsal and orbital regions displayed the greatest differences while the mesial region showed the least change. We also found that minicolumns in the brain of a 3-year-old autistic child were indistinguishable...
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ackground: Evidence from behavioral, imaging, and postmortem studies indicates that the frontal lobe, as well as other brain egions such as the cerebellum and limbic system, develops abnormally in children with autism. It is not yet clear to what extent the rontal lobe is affected; that is, whether all regions of frontal cortex show the same signs of structural maldevelopment. ethods: In the pr...
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Autism is a severe neurodevelopmental disorder that is characterized by impaired language, communication, and social skills. In regressive autism, affected children first show signs of normal social and language development but eventually lose these skills and develop autistic behavior. Protein kinases are essential in G-protein-coupled, receptor-mediated signal transduction and are involved in...
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One of the most important factors in drug addiction is stress. It has been shown that animals with prenatal stress history are more risky for drug dependence. It have also been shown that frontal cortex play a role in drug dependence. In the present study the effects of two kinds of mild stress during pregnancy on the development of frontal cortex in Wistar rats (250-300 g) were investigated. F...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2019
ISSN: 1664-8021
DOI: 10.3389/fgene.2019.00707